harmine相关论文
Harmine is a β-carboline alkaloid isolated from Banisteria caapi and Peganum harmala L with various pharmacological act......
目的:本研究基于患者的临床数据,探讨外周血细胞免疫紊乱和血清LAG3对于帕金森病（Parkinson’s disease,PD）的影响。探讨PD发病过程......
Synthesis and characterization of N-caprinoyl-N-arginine chitosan as self-assembled micelles carrier
Objective: Based on natural biodegradable chitosan,we connected arginine to the 6-amino-acid-position of chitosan in ord......
Novel self-assembled micelles based on palmitoyl-trimethyl-chitosan for efficient delivery of harmin
Objective: A new material: trimethyl-palmitoyl-chitosan (TPCS) was synthesized and modified with lactobionic acid to obt......
Pharmacokinetics,tissue distribution and accumulation of harmine in mice following single and multip
The pharmacokinetics and tissue distribution of harmine were investigated in mice after oral administration at dose of 4......
A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboli
Harmine, a beta-carboline alkaloid, is widely distributed in the plants, marine creatures, insects, mammalians as well a......
骆驼蓬系蒺藜科骆驼蓬属多年生草本植物Peganum Harmala L。新疆医学院附属第二医院将骆驼蓬粗制剂用于治疗消化道肿瘤,初步观察......
A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carbolin
Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in......
以一些独立机制为靶点的组合治疗系统可用于治疗肿瘤.本研究采用薄膜分散法结合pH梯度法制备包载阿霉素和去氢骆驼蓬碱的脂质体,进......
目的观察对去氢骆驼蓬碱和阿苯达唑单用及联合用药对小鼠腹腔成熟包虫囊的作用。方法通过对昆明种小鼠腹腔注射细粒棘球蚴原头节制......
The preparation and properties of Harmine - gelatin microspheres ( HM - GMS) were reported. The characteristics of pharm......
目的 探讨骆驼蓬碱介导COX-2表达水平抑制骨肉瘤细胞增殖与凋亡的作用.方法 体外培养人骨肉瘤细胞U2OS细胞系,随机分为对照组、研......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的:利用植物悬浮细胞培养体系对骆驼蓬碱进行生物转化.方法:利用长春花、一叶萩、烟草和金银花植物悬浮细胞培养体系转化骆驼蓬......
采用密度泛函理论,M062X方法,使用6-31g(d)基组,对去氢骆驼蓬碱分子进行结构优化,通过频率计算得到该分子的红外光谱,并和实验获得......
BACKGROUND:Harmine has antitumor and antinociceptive effects,and inhibits human DNA topoisomerase.However no detailed da......
目的探讨去氢骆驼蓬碱对人胃癌MKN-45细胞环氧化酶-2(cyclooxygenase-2,COX-2)表达、迁移和侵袭的影响。方法 MKN-45细胞接种于含1......
目的本研究旨在研究去氢骆驼蓬碱体外诱导Jurkat细胞凋亡及其可能机制。方法采用MTT法测定去氢骆驼蓬碱对Jurkat细胞的生长抑制作......
目的：研究去氢骆驼缝碱（ｈａｒｍｉｎｅ，ＨＡＲ）静脉注射乳剂在大鼠体内的药动学和小鼠体内的组织分布。方法：ＨＰＬＣ法测定血药浓度，计算药动学参数；用放射性同位素示......
目的：定量评价静脉注射用乳剂作为药物载体给药后对主要脏器的靶向性并对给药系统靶向性的定量评价参数进行讨论和评价。方法：用＾３Ｈ标记......
笔者用反相离子对高效液相色谱法对骆驼蓬种子所含有效成分去氢骆驼蓬碱提取工艺进行了研究,工艺合理可行,结论合理可靠.......
背景:骆驼蓬碱可通过下调环氧合酶-2(COX-2)表达抑制胃癌细胞增殖,但其分子机制尚未完全明确。目的:研究骆驼蓬碱对胃癌细胞增殖、......
目的：建立去氢骆驼蓬碱（harmine)口服乳剂的体内外含量测定方法，并研究该乳剂在小鼠体内的组织分布。方法：采用高效液相色谱法（HPLC）测定......
目的:考察去氢骆驼蓬碱(harmine)口服乳剂的物理性质.方法:分别采用界面电泳法、旋转式粘度计、电导法等方法,测定口服乳剂的电学......
目的:考察去氢骆驼蓬碱明胶微球(HM-GMS)中盐酸去氢骆驼蓬碱(HM)含量测定方法及微球热解稳定性.方法:用紫外分光光度(UV)法和反相......
目的:比较去氢骆驼蓬碱磁固体脂质纳米粒(HM-MSLN)的不同制备方法,以单因素考察结合星点设计响应面法优化制备工艺。方法:比较薄膜......
采用电导法对去氢骆驼蓬注射用乳剂的凝聚动力学进行了研究，求出凝聚速度方程和２５℃时半凝聚期，从而定量地预测了这一分散体系的物理稳......
目的：探讨具有不同分配系数的药物在乳剂中的相分布和体外释药性能。方法：经测定去氢骆驼蓬碱（Ｈａｒ）和去氢骆驼蓬碱盐酸盐（Ｈａｒ．ＨＣＬ）具有不同的辛醇／水......
